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Mohler, J. & Vani, K. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 957–971 (1992).

Hsia, E. Y. C. et al. Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs. Nat. Commun. 8, 1275 (2017). Henderson, N. C., Rieder, F. & Wynn, T. A. Fibrosis: from mechanisms to medicines. Nature 587, 555–566 (2020). Lou E, Schomaker M, Wilson JD, Ahrens M, Dolan M, Nelson AC. Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib. Cancer Biol Ther. 2016;22:1–7. From fatty suet balls and cakes for extra energy to delicious and nutritious nuts and seeds, you can find all kinds of affordable goodies that birds will love right here at B&M.Gilbane, A. J., Denton, C. P. & Holmes, A. M. Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells. Arthritis Res. Ther. 15, 215 (2013). Yao, S., Lum, L. & Beachy, P. The Ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 125, 343–357 (2006). Rohatgi, R., Milenkovic, L. & Scott, M. P. Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372–376 (2007).

Myers, B. R., Neahring, L., Zhang, Y., Roberts, K. J. & Beachy, P. A. Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium. Proc. Natl Acad. Sci. USA 114, E11141–E11150 (2017). Lu, F. Y., Chen, R., Zhou, M. & Guo, Y. Hedgehog signaling modulates cigarette-induced COPD development. Exp. Ther. Med. 22, 729 (2021).Jiang, Y., Benz, T. L. & Long, S. B. Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science 372, 1215–1219 (2021). Machado, M. V. & Diehl, A. M. Hedgehog signalling in liver pathophysiology. J. Hepatol. 68, 550–562 (2018). Any additional leaf litter near the house may be claimed by a hedgehog and taken inside to be used as extra bedding. Instead of a house, you could simply make a messy patch of leaves and logs in a quiet area of your garden. A hedgehog may choose to hibernate or nest there.

Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003;3(12):903–11. Of course, larger non-domesticated creatures need our support too. From squirrel feeders to hedgehog food, our range of affordable products for woodland and hedgerow animals can make all the difference to the wildlife in your area - without breaking the bank! Dwyer, J. R. et al. Oxysterols are novel activators of the Hedgehog signaling pathway in pluripotent mesenchymal cells. J. Biol. Chem. 282, 8959–8968 (2007).Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002;99(22):14071–6.

Epstein, J. B., Smutzer, G. & Doty, R. L. Understanding the impact of taste changes in oncology care. Support. Care Cancer 24, 1917–1931 (2016).Findakly, S. et al. Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. J. Cell Biol. https://doi.org/10.1083/jcb.202002026 (2021). Lao, T. et al. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 7, 12 (2015). Wu VM, Chen SC, Arkin MR, Reiter JF. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci USA. 2012;109(34):13644–9. TY, WT, and YL searched literature, designed the research, and wrote the manuscript. TY, JW, JY, and WH performed the experiments, collected data, and analyzed the data. LL provided scientific suggestions and contributed to the manuscript revision. WT and YL supervised the project. All authors contributed to the article and approved the submitted version. Funding Woods, I. G. & Talbot, W. S. The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. PLoS Biol. 3, e66 (2005).